The vast majority of supplement companies continue to release underdosed and unproven products. They attempt to deceive the consumer with outlandish claims and snazzy marketing campaigns. When the consumer eventually catches on to these companies act, supplement companies then revert to other duplicitous tactics, redesigning their container labels but they fail to make any meaningful changes to the actual product formula. Olympus Labs will not engage in such shady practices. We are committed to providing Innovation, Value and Results for the DemiGod Nation.
To hold true to that commitment the DemiGod R&D team is continuously striving to bring the most effective products to the supplement market. That process includes evaluating our own product lineup to determine whether any enhancements can be made based on new research, technologies, and or delivery systems. Case in point, was the impressive improvement we made to our (-)-epicatechin product, EP1C, with the release of EP1C UNLEASHED. Olympus Labs developed an exciting new delivery system, PhytoFUSETM, to increase the bioavailability and absorption of (-)-epicatechin. EP1C UNLEASHED established PhytoFUSETM as the premier methodology to increase the bioavailability and absorption of nutraceuticals ingredients, especially herbal ingredients and their extracts which tend to have poor absorption in the body.
The feedback from EP1C UNLEASHED has been exceptional, especially from non-responders to standard (-)-epicatechin. With the successful implementation of the PhytoFUSETM technology a wealth of possibilities was UNLEASHED. Join us DemiGod nation as Olympus Labs embarks on a revolution in supplementation with the PhytoFUSETM Series. The PhytoFUSETM Series will be a suite of supplements that embrace our commitment to Innovation and accomplishing the unimaginable!
Olympus Labs is proud to present the next wave of the PhytoFUSETM Series with STR3NGTH UNLEASHED and DERMASTR3NGTH UNLEASHED as another natural option to unearth your true anabolic potential. STR3NGTH UNLEASHED is the sequel to STR3NGTH, the capsule product featuring 5a-Hydroxy Laxogenin. While STR3NGTH represented a key development in the field of natural anabolics, at Olympus Labs we knew that the efficacy could be enhanced if only its bioavailability and absorption could be increased. To realize that objective, STR3NGTH UNLEASHED utilizes absorption enhancers with the now proven PhytoFUSETM technology to further enhance the bioavailability of Laxogenin. DERMASTR3NGTH UNLEASHED contains the same active ingredients, but in a transdermal version.
Not only does PhytoFUSETM technology help with absorption & bioavailability, but it also helps with distribution of the phytoFUSED ingredient in the body!
It will now be possible to realize the full potential of 5a-Hydroxy Laxogenin; increased strength, glucose uptake into the muscles and protein synthesis resulting in improved body composition. But that’s not all, it is believed Laxogenin can provide cortisol control, improve thyroid function and improve joint function. Do not be deterred from a prior experience with Laxogenin. There was doubt when EP1C UNLEASHED was released, but no longer! Olympus Labs converted the non-believers and the next wave in the PhytoFUSETM Series will correct the injustice that is found in the poor bioavailability and absorption of other laxogenin products.
STR3NGTH UNLEASHED and DERMASTR3NGTH UNLEASHED are here to UNLEASH the TRUE potential of this potent ingredient. It is totally understandable to get excited, Olympus Labs has accomplished another unthinkable feat and you, fellow DemiGod, are the benefactor. Get ready to obliterate the barriers to success and UNLEASH your TRUE STR3NGTH!
- Extreme Strength Gains
- Fuller Muscles
- Cortisol, Thyroid and Glucose Control
- Joint Repair
- Enhanced Absorption
5a-Hydroxy Laxogenin is a steroidal sapogenin isolated from Smilax sieboldi, a spirostanic analogue of the brassinosteroid. Brassinosteroids are plant-derived polyhydroxylated derivatives of 5a-cholestane, structurally similar to cholesterol-derived animal steroid hormones and insect ecdysteroids. They are found in small quantities in plants and foods such as pollen, seeds, and leaves. They are similar to animal steroids but function very differently at the cellular level. Plant brassinosteroids signal through a cell surface receptor kinase-mediated signal transduction pathway while animal steroid hormones act through the nuclear receptor family of transcription factors.
Brassinosteroids have a wide array of physiological and pharmacological effects in animals and insects including modulation of protein synthesis and carbohydrate metabolism. Research in animals suggest that brassinosteroids can stimulate protein synthesis and inhibit protein degradation in part by inducing Akt phosphorylation. Akt is a serine/threonine kinase that signals downstream of growth factor receptors and phosphoinositide-3 kinase PI3K. Akt stimulates glucose uptake, glycogen synthesis, and protein synthesis via Akt/mTOR and Akt/GSK-3β signaling networks and inhibits apoptosis and protein degradation in skeletal muscle by inactivating FoxO transcription factors leading to increased lean mass. In addition, unlike mammalian steroids, brassinosteroids are not hampered by androgenic side effects.
An animal study was conducted to assess the efficacy of the brassinosteroid, 28-Homobrassinolide (HB) on L6 rat skeletal muscle cells (EC50 4 μM). Oral administration of HB (20 or 60 mg/kg/d for 24 d) to healthy rats fed normal diet (protein content 23.9%) increased food intake, body weight gain, lean body mass, and gastrocnemius muscle mass as compared with vehicle-treated controls. The effect of HB administration increased slightly in animals fed a high-protein diet (protein content 39.4%). Both oral (up to 60 mg/kg) and subcutaneous (up to 4 mg/kg) administration of HB showed low androgenic activity and no direct binding to the androgen receptor in vitro. HB treatment was also associated with improved physical fitness of untrained healthy rats, as evident from a 6.7% increase in lower extremity strength, measured by grip test. In the gastrocnemius muscle of castrated animals, HB treatment significantly increased the number of type IIa and IIb fibers and the cross-sectional area of type I and type IIa fibers.
These findings suggest that oral application of HB triggers selective anabolic response with minimal or no androgenic side-effects and begin to elucidate the putative cellular targets for plant brassinosteroids in mammals. Furthermore, they indicate HB dose and time dependently stimulated protein synthesis and inhibited protein degradation in L6 rat skeletal muscle cells (EC50 4 μM), in part by inducing Akt phosphorylation (Fig.1 and Fig. 2)
Figure 1. Concentration and time-dependent effects of HB on protein synthesis and degradation in L6 rat myotubes.
Figure 2. HB increases Akt (Ser473) phosphorylation in L6 myotubes.
Unfortunately there is a lack of research and clinical trials on 5a-Hydroxy Laxogenin itself which is why several companies make product claims for Laxogenin based on its steroidal pharmaceutical anabolic counterpart. Although Olympus Labs never made products claims for our Laxogenin products, STR3NGTH and DERMASTR3NGTH based on this other pharmaceutical anabolic data, we did have high hopes based on the data cited above. Since 5a-Hydroxy Laxogenin has been available for a sufficient time period we were able to validate its efficacy as a bodybuilding supplement. Through anecdotal feedback we learned that actual results from STR3NGTH were similar to EP1C, where some users experienced modest strength increases while others experienced little to no results. Fortunately, the transdermal version, DERMASTR3NGTH yielded much better results but still did not coincide with the potential benefits based on the research on Brassinosteroids. We will seek to remedy that as we did with (-)-epicatechin by pairing Laxogenin with the proven PhytoFUSETM technology.
PhytoFUSETM – Enhanced Delivery System
STR3NGTH UNLEASHED and DERMASTR3NGTH UNLEASHED utilize a unique delivery technology, PhytoFUSETM, to enhance the bioavailability and absorption of 5a-Hydroxy Laxogenin. On top of this they help with distribution of the phytoFUSED ingredient in the body! Olympus Labs does not spend copious amounts of money on marketing campaigns, instead we spend available funds on research like the substantial investment in the PhytoFUSETM delivery system. The results DemiGods have seen from EP1C UNLEASHED leave no doubt that PhytoFUSETM is an effective enhanced delivery system. What other company can claim that?
Research has shown that this method of delivery can enhance potency anywhere from 2x-6x! That means that STR3NGTH UNLEASHED and DERMASTR3NGTH UNLEASHED will be 200 – 600% more potent than any other Laxogenin product on the market! This enhanced delivery system, unique to Olympus Labs, utilizes specific lipids to complex with Laxogenin on a molecular level, allowing for greater solubility and enhanced bioavailability/absorption, helping to effectively shuttle the active ingredient to the intestines where it can be taken up while preventing degradation throughout the process. This means that more ingredient is delivered to the site where it can be utilized effectively, ready to be delivered to the bloodstream and flood your muscles with potent myogenic factors needed to transcend into becoming a demigod!
With the success of EP1C UNLEASHED, it was a no brainer to apply the PhytoFUSETM technology to other ingredients that are inhibited by poor bioavailability and absorption. Unbeknownst to us at the time we introduced EP1C UNLEASHED, we were embarking on the dawning of a new era of the PhytoFUSETM Series. STR3NGTH UNLEASHED and DERMASTR3NGTH UNLEASHED are here to unlock the TRUE potential of the potent ingredient, 5a-Hydroxy Laxogenin. Get ready to obliterate the barriers to success and UNLEASH your TRUE STR3NGTH!
Despite this exciting breakthrough, Olympus Labs will not relent, as you grow in the gym with STR3NGTH UNLEASHED and DERMASTR3NGTH UNLEASHED you can bet the PhytoFUSETM Series will grow. DemiGod nation, what will be the next TR1UMPH? Stay Tuned!
I TEST1FY that I will CONQU3R, I will ENDUR3, I will TR1UMPH, and UNLEASH the STR3NGTH needed to crush any barrier put forth before me!
- Iglesias-Arteaga M et al. J. Braz. Chem. Soc. vol.16 no.3a São Paulo May/June 2005. A convenient procedure for the synthesis of 3b-hydroxy-6-oxo-5a-steroids. Application to the synthesis of laxogenin.
- Kubo S e al. Phytochemistry. 1992 Jul;31(7):2445-50. Steroidal saponins from the rhizomes of Smilax sieboldii.
- Debora E et al. FASEB J. 2011 Oct; 25(10): 3708–3719. doi: 10.1096/fj.11-181271. Anabolic effect of plant brassinosteroid
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