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SUP3R DHEA Subscription

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SUP3R DHEA by Olympus UK (120mL)

 

It’s no secret, Prohormone cycles are extremely popular with those looking to

increase muscle mass and strength, but as we all know, they come with certain drawbacks. Perhaps

youve used such products before, only to experience these drawbacks firsthand. Ask yourself, have you

ever felt lethargic while on cycle? Have you ever felt that lethargy limited your ability to get the most

out of your cycle? Perhaps you felt you could have pushed harder, seen better results, if only you had

the energy? Or maybe youve never done a cycle, and the concerns regarding lethargy and low libido are

holding you back, causing you to seek a solution to such issues before taking the next step. Well look no

further, SUP3R-DHEA was designed specifically to UNLEASH your inner Demi-God, crush on cycle

lethargy and take your workouts to the next level!

 

So what is SUP3R-DHEA?

It is a premium quality transdermal product which can aid those seeking to

reduce body fat, increase lean muscle mass and enhance performance! But most importantly, it helps

keep the body hormonally balanced during a suppressive cycle. So how does SUP3R-DHEA do this? Well,

while many people are under the impression that they fully understand the suppression of the HPTA

that occurs while on cycle, one important aspect is often overlooked. When the HPTA is suppressed, its

not only Testosterone, DHT and Estrogen that decline in production, but DHEA and Pregnenolone as

well. These two hormones are just as vital to various physiological processes as Testosterone, DHT and

Estrogen are! In fact, Endocrinologists frequently put men who are prescribed Testosterone-

Replacement Therapy (TRT) on supplemental DHEA and Pregnenolone for this very reason! Thus, SUP3R-

DHEA was formulated with this in mind.

 

So what does SUP3R-DHEA consist of?

Well, it’s primary ingredient is Dehydroepiandrosterone or DHEA,

which is sometimes referred to by its synonyms androstenolone, dehydroepiandrostenedione or

didehydroepiandrosterone and occasionally by its nomenclature 3ß-hydroxyandrost- 5-en- 17-one or 5-

androsten-3ß- ol-17- one. It is a naturally occurring endogenous hormone, and in humans it is the

most abundant hormone in circulation, where it is produced in the adrenal glands, the brain and

the gonads. [1-4] It functions predominantly as a metabolic intermediate in the biosynthesis of the

androgen and estrogen sex hormones. [1][5] But it also has a significant number of potential biological

effects in its own right, such as binding to an array of nuclear and cell surface receptors and acting as a

neurohormone. [6-7] Which, as a neurohormone, it has important effects on neurological and psychological

functioning. [8-10]

 

Now, it would be tedious to attempt to cover DHEAs mechanisms of action in their entirety. With this in

mind, the most important mechanism worth highlighting is its function as an endogenous precursor, or

;prohormone;, to more potent androgens such as Testosterone and Dihydrotestosterone (DHT). [13] It

also has the potential to convert to hormones such as 7-beta DHEA or 7-Keto DHEA which are associated

with an increase in the rate of fat loss, while simultaneously aiding in muscle accretion. [15][23-27]

When DHEA is supplemented orally, not all of these effects and conversions are seen, as the digestive

track does not have the same enzyme activity as the skin. [14] But when applied topically to the skin,

which is highly concentrated with hormoneo enzymes, the potential for DHEA to convert to stronger

hormones such as androstenediol, androstenedione and testosterone in greatly enhanced. [14-22]

Though DHEA has been noted to possess some degree of androgenic activity in its own right, with it

acting as a low affinity weak partial agonist of the androgen receptor. There has even been speculation

by some that DHEA can act as an anti-androgen due to its intrinsic activity at the receptor being quite

weak and its competition for binding with full agonists like testosterone, potentially causing it to behave

more like an antagonist depending on circulating Testosterone and Dihydrotestosterone (DHT) levels.

However, because its affinity for the receptor is very low it is unlikely to be of much significance under

normal circumstances. [11-12] So such speculation can be disregarded.

 

But DHEA isn’t the only shining star, SUP3R-DHEA has yet another vital hormone in its formula,

Pregnenolone, which is also known as P5 and is sometimes referred to by its nomenclature 3ß-

hydroxypregn-5- en-20- one. Like DHEA, it too is a naturally occurring endogenous hormone, and

in fact is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and

estrogens, as well as the neuroactive hormoness. Though Pregnenolone is also biologically active in its own

right, and acts as a powerful neurohormone which can potentially enhance both memory and focus. [28-

30][40] This is because Pregnenolone, like DHEA, belongs to the group of neurohormoness that are found in

high concentrations in certain areas of the brain. Neurohormones such as Pregnenolone affect synaptic

functioning, are neuroprotective and enhance myelinization. It is under investigation for its potential to

improve cognitive and memory functioning, [40] as well as being considered as a potential treatment for

schizophrenia. [39]

 

And though DHEA and Pregnenolone fulfill many vital physiological needs, they both have the potential

to convert to Estrogen. Now while Estrogen does play a role in anabolism, and fulfills vital physiological

needs as well, too much can result in side effects. Because of this, SUP3R-DHEA was formulated with

estrogen control in mind. Acacetin, which is sometimes referred to by its nomenclature 4-Methoxy- 5,7-

dihydroxyflavone, is a natural O-methylated flavone found in Turnera Diffusa (Damiana) [41], Robinia

Pseudoacacia (Black Locust), Betula Pendula (Silver Birch) [42], and in the fern Asplenium Normale. [43]

Researchers at the University of Mississippi performed a study aimed at investigating the anti-aromatase

activity and estrogenic activity of constituents isolated from Turnera Diffusa. In the study, 24

compounds were isolated from the leaves of Turnera Diffusa and evaluated for aromatase activity by

using a tritiated-water release assay and for estrogenic activity by using yeast estrogen screen (YES)

assay. Among the compounds tested, Pinocembrin and Acacetin were shown to be the most potent

aromatase inhibitors. However, Pinocembrin was found to have estrogenic activity, while Acacetin

showed no estrogenic activity whatsoever. In the study, Acacetin was found to suppress aromatase

activity up to 63 percent. [41] This is important because aromatase is the enzyme required for

conversion to Estrogen, which at excessive levels is associated with negative side effects such as

bloating, increased water retention and gynecomastia. Thus, Acacetin helps to mitigate potential

estrogenic side effects that may occur from DHEA or Pregnenolone supplementation.

 

The fourth and final component of SUP3R-DHEA is Osthole, which is sometimes referred to by its

nomenclature 7-Methoxy- 8-(3- methyl-2- butenyl)coumarin or 7-Methoxy- 8-isopentenylcoumarin.

Osthole is a naturally occurring O-methylated coumarin found in plants such as Angelica Archangelica,

Angelica Pubescens and Cnidium Monnieri. Like the other components of SUP3R-DHEA, Osthole has

numerous effects. It is a calcium channel blocker, it dramatically decreased lipid accumulation in a quail

model, and its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of

Osthole as a therapeutic agent for the treatment of neurodegenerative disorders.

 

Osthole is also an active constituent of Cnidium Monnieri, which has been used as a pro-erectile herb in

traditional Chinese medicine, and appears to be able to cause pro-erectile muscular relaxation in a dose-

dependent manner, [51-52] possibly via phosphodiesterase inhibition, as Osthole appears to potentiate

cGMP induced relaxation as well as nitric oxide. [52] But there may be other possible mechanisms at

work, such as central (brain) effects due to the ability to induce glutaminergic neurotransmission.

Another interesting ability of Osthole is that it is able to reduce fatty liver induced by alcohol, as well as

induced by milk-fat [44][46-48], as well as lower triglyceride content in liver tissue [49], and induce PPAR

alpha activation which can then reduce DGAT and HMG-CoA activity, resulting in a shift towards lipid

mobilization rather than storage. [45] It also suppresses the mRNA transcription rates of Fatty Acid

Synthase by 9.1%-38.7%, as well as suppresses the LDL receptor in the liver by 54.7%-78.9%. [49] It has

been implicated in increasing AMPK-mediated glucose uptake into myocytes in dose and time

dependent manners, with increases in glucose uptake via GLUT4 translocation induced by AMPK. [50]

Osthole may also phosphorylate (activate) Akt, as well as the downstream proteins of AS160 and GSK3,

which is yet another mechanism by which GLUT4 may be increased. [50] Osthol also appears to be a

mixed inducer of PPAR alpha and gamma activity [48], which is one of the mechanisms by which it

protects against fatty liver. [45] PPAR alpha and PPAR gamma activation is a mechanism of fat loss in

some supplements, thus Osthole holds potential as a fat loss agent.

 

Now that weve covered the individual ingredients, let’s delve into the formulation as a whole. One

important aspect of SUP3R-DHEA is that none of its ingredients are methylated, so there is no need for

liver support such as TUDCA while using SUP3R-DHEA because it is not hepatotoxic. And with its

transdermal delivery system, it bypasses first-pass hepatic metabolism by going direct-to- bloodstream.

In fact, SUP3R-DHEA is perfect for transdermal delivery because all ingredients in its formulation

conform to the ;500 Dalton rule; which states the molecular weight of a compound must be under 500

Dalton to allow skin absorption. And SUP3R-DHEA does exactly this, with Pregnenolone weighing

316.47g/mol, DHEA weighing 288.42g/mol, Acacetin weighing 284.26g/mol, and Osthole weighing

244.28g/mol. All known topical drugs used in transdermal drug-delivery systems are under 500 Dalton.

[53] Transdermal delivery also comes with the added benefit of releasing compounds slowly over a

longer period of time, meaning blood levels wont rapidly peak and then dissipate as can be seen with

oral administration. This translates to stable blood levels and better results.

 

But that’s not all! SUP3R DHEA delivers a jaw-dropping 12g DHEA, 6g Cnidium Monnieri Extract (3g being

pure Osthole), 3g Pregnenolone and 3g Acacetin per bottle!

 

So as you can see, SUP3R-DHEA is a well-rounded, premium-quality transdermal product that has

numerous benefits to anyone on cycle! Its effects go above and beyond just that of a simple Test Base

mitigating the effects of lethargy brought on by prohormone and designer hormone use!

 

 

~Effects of SUP3R-DHEA:

It is worth highlighting the numerous effects that SUP3R-DHEA has, and how it could be a beneficial

addition to a cycle:

-Functions as a Test Base

-Provides Vital Hormones (For Various Physiological Functions)

-Improves Cognitive Abilities [31-32]

-Improves Libido/Sex Drive

-Improves Sleep Quality

-Improves Sense of Well-Being [33-34]

-Increases Stamina

-Increases Energy

-Mitigates Lethargy

-Enhanced Athletic Performance

-Enhances Strength

-Enhances Recovery [35-38]

-Aids in Estrogen Management

 

~Side Effects of SUP3R-DHEA:

In regards to short term usage, several studies have shown that there are few adverse effects. In one

study by Chang et al., DHEA was administered at a dosage of 200mg/day for a whopping 24 weeks with

only slight androgenic effects noted. [54] Another study, which utilized dosages up to 400mg/day for 8

weeks, also resulted in few adverse events reported. [55] Therefore we can extrapolate that higher

dosages and longer usage is both safe and relatively side effect free.

Though SUP3R-DHEA is designed to be used on-cycle when the HPTA is suppressed, it is worth stating

that due to the hormones it can potentially convert to, SUP3R-DHEA can itself be suppressive as well.

This is of little concern for those stacking SUP3R-DHEA because it is intended to function as a Test Base,

helping to mitigate lethargy, low libido, etc. And unlike other hormonal products, SUP3R-DHEA does not

have a negative impact on cholesterol levels, the liver, the prostate or the heart.

 

 

~Dosing, Cycle Length, Stacking and Timing:

SUP3R-DHEA is a very versatile product, and dosing can be adjusted as needed, though the general

guidelines for dosing are as follows:

150-200lbs: 1 – 1.5 pumps with wrists on to dry skin only!

200-225lbs: 1.5 – 2 pumps with wrists on to dry skin only!

225lbs+: 2 – 2.5 pumps with wrists on to dry skin only!

(1 pump = 2mL)

 

 

 

SUP3R-DHEA is best utilized as a Test Base while using suppressive compounds on-cycle. It is typically

used for 30-60 days, which is the traditional cycle length range. Because of its mild nature, it is

considered to be a fantastic addition to all cycles. SUP3R-DHEA can be applied at any time during the

day, either once or several times daily. As covered earlier, SUP3R-DHEA supplies DHEA and

Pregnenolone due to natural production being suppressed on cycle, this is why it is often classified as a

Test Base. However, it can be stacked with 4-Andro products such as SUP3R-4 and EpiAndro products

such as SUP3R-EPI to fully supply all suppressed hormones, leading to optimal results while on cycle.

 

~Post-Cycle Therapy (PCT) for SUP3R-DHEA:

As stated earlier, due to the hormones SUP3R-DHEA can potentially convert to, it has the ability to be

suppressive. Though it is formulated to be stacked with other suppressive compounds, which would

require a proper PCT regardless, it must be noted that a PCT is recommended. Depending upon the

cycle, and other suppressive compounds involved, the degree of PCT required will vary. It is best to

follow the recommended guidelines for PCT listed under the product that SUP3R-DHEA is being utilized

as a Test Base for. Those who are on Testosterone-Replacement Therapy (TRT) can use SUP3R-DHEA

for extended periods of time due to their HPTA being shutdown indefinitely.

~SUP3R-DHEA Example Cycles & Stacking Guidelines:

There are near limitless cycles that SUP3R-DHEA can be stacked with, here are just a few examples to

better illustrate the versatility of the compound. Note: These are just simple examples, and cycles can

be ran longer than 4 weeks, dosed at different times, and stacked with other compounds.

*Advanced/Experienced – Bulking Cycle: (30 Day Cycle, Over 4 Weeks)

-SUP3R- DHEA — – (As directed on bottle)

-SUP3R- 1 — — — — — 330/330/330/330 (1 bottle Olympus UK SUP3R-1 ELITE – 90 Caps)

*Advanced/Experienced – Recomp Cycle: (30 Day Cycle, Over 4 Weeks)

-SUP3R- DHEA — — (As directed on bottle)

-SUP3R- 1 — — — — — – 330/330/330/330 (1 bottle Olympus UK SUP3R-1 ELITE – 90 Caps)

*Advanced/Experienced – Cutting Cycle: (30 Day Cycle, Over 4 Weeks)

-SUP3R- DHEA — — — (As directed on bottle)

-SUP3R- EPI — — — — — 1000/1000/1000/1000 (1 bottle Olympus UK SUP3R-EPI ELITE – 120 Caps)

-IGNIT3 — — — — — — — – 5/5/5/5 [Caps per day] (1 bottle Olympus Labs IGNIT3 – 150 Caps)

*Post Cycle Therapy (PCT): (30 Days, Over 4 Weeks)

-Olympus Labs SUP3R PCT (As indicated on label)

Ingredients:

 

super-dhea-ingredients

 

Directions:

150-200lbs: 1 – 1.5 pumps with wrists on to dry skin only!

200-225lbs: 1.5 – 2 pumps with wrists on to dry skin only!

225lbs+: 2 – 2.5 pumps with wrists on to dry skin only!

(1 pump = 2mL)

~References:

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[2] William F Ganong MD, Review of Medical Physiology, 22nd Ed, McGraw Hill, 2005, page 362.

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[5] Thomas Scott (1996). Concise Encyclopedia Biology. Walter de Gruyter. p. 49. ISBN 978-3- 11-010661-

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[8] Abraham Weizman (1 February 2008). Neuroactive in Brain Function, Behavior and

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[26] The effect of 7 – keto Naturalean on weight loss: A randomized, double blind placebo controlled

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[43] UmiKalsom, Yusuf; Harborne, Jeffrey B. (1991). ;Flavonoid distribution in asplenioid ferns;.

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[44] Zhang J, et al Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative

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[45] Sun F, et al Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic

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[46] Zhang Y, et al Therapeutic effect of osthole on hyperlipidemic fatty liver in rats . Acta Pharmacol Sin.

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[47] Zhang Y, et al Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of

PPARalpha/gamma in fat milk-induced fatty liver rats . J Asian Nat Prod Res. (2008)

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in vitro . J Urol. (2000)

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